University of Tasmania
Browse

File(s) under permanent embargo

Human pluripotent stem cells for the modelling of diseases of the retina and optic nerve: toward a retina in a dish

journal contribution
posted on 2023-05-20, 09:17 authored by Lidgerwood, GE, Alexander HewittAlexander Hewitt, Pebay, A
Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retina and optic nerve. These cells can then be used to study fundamental biology as well as disease modelling and subsequent screening of potential treatments. Many models of differentiation and modelling have relied on two-dimensional monocultures of specific cell types, which are not representative of the complexity of the human retina and optic nerve. Hence, more complex models of the human retina and optic nerve are required. Three-dimensional organoids and emerging cell culture methods may provide more physiologically relevant models to study developmental biology and pathology of the retina and optic nerve.

History

Publication title

Current Opinion in Pharmacology

Volume

48

Pagination

114-119

ISSN

1471-4892

Department/School

Menzies Institute for Medical Research

Publisher

Elsevier Sci Ltd

Place of publication

The Boulevard, Langford Lane, Kidlington, Oxford, England, Oxon, Ox5 1Gb

Rights statement

Copyright 2019 Elsevier Ltd.

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Categories

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC