The unique characteristics of dental pulp stem cells (DPSCs), like multi-lineage differentiation, have attracted considerable interest among clinicians and researchers for the treatment of various diseases. Platelet-derived concentrates (PRSs) are utilized for wound healing, due to the plethora of growth factors that are released from platelets. In this study, DPSCs were cultured with one of the three culture supplements, including fetal bovine serum (FBS), human platelet-rich plasma (PRP), and human platelet lysate (HPL). The viability effects of these platelet-derived culture supplements on DPSCs were evaluated using hybrid approaches of fuzzy-genetic methods. The results showed that DPSCs cultured in HPL have higher viability than FBS and PRP. It is suggested that fuzzy-genetic algorithm (GA) is an accurate approach to estimate the effect of platelet concentrates on the proliferation of stem cells derived from the human tooth.
History
Publication title
Applied Medical Informatics
Volume
41
Pagination
93-101
ISSN
1224-5593
Department/School
School of Health Sciences
Publisher
Romanian Society of Applied Medical Informatics (S R I M A)
Place of publication
Romania
Rights statement
Copyright 2019 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/