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Hybrid protein-inorganic nanoparticles: From tumor-targeted drug delivery to cancer imaging

journal contribution
posted on 2023-05-19, 05:19 authored by Elzoghby, AO, Hemasa, AL, Freag, MS
Recently, a great interest has been paid to the development of hybrid protein-inorganic nanoparticles (NPs) for drug delivery and cancer diagnostics in order to combine the merits of both inorganic and protein nanocarriers. This review primarily discusses the most outstanding advances in the applications of the hybrids of naturally-occurring proteins with iron oxide, gadolinium, gold, silica, calcium phosphate NPs, carbon nanotubes, and quantum dots in drug delivery and cancer imaging. Various strategies that have been utilized for the preparation of protein-functionalized inorganic NPs and the mechanisms involved in the drug loading process are discussed. How can the protein functionalization overcome the limitations of colloidal stability, poor dispersibility and toxicity associated with inorganic NPs is also investigated. Moreover, issues relating to the influence of protein hybridization on the cellular uptake, tumor targeting efficiency, systemic circulation, mucosal penetration and skin permeation of inorganic NPs are highlighted. A special emphasis is devoted to the novel approaches utilizing the protein-inorganic nanohybrids in combined cancer therapy, tumor imaging, and theranostic applications as well as stimuli-responsive drug release from the nanohybrids.

History

Publication title

Journal of Controlled Release

Volume

243

Pagination

303-322

ISSN

0168-3659

Department/School

School of Pharmacy and Pharmacology

Publisher

Elsevier BV

Place of publication

Netherlands

Rights statement

© 2016 Elsevier B.V. All rights reserved.

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the health sciences

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