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Hypergastrinaemia: a new mechanism
journal contribution
posted on 2023-05-17, 08:03 authored by Deprez, PH, Ghosh, P, Goodlad, RA, Lacey, SL, Millership, S, Playford, RJ, Lee, CY, Calam, JThe mechanism by which lack of gastric acid causes hypergastrinaemia was investigated in seven patients with pernicious anaemia. Perfusion of gastric juice from the fasting patients (adjusted to pH 7·0) into the stomachs of conscious rats caused a significant rise in plasma gastrin (median 14 [range 2-20] pmol/l to 27 [12-65] pmol/l; p<0·01), whereas perfusion of bicarbonate buffer (18 [13-23] pmol/l to 20 [9-25] pmol/l) or gastric juice from a duodenal ulcer patient (also pH 7·0; 13 [3-30] pmol/l to 17 [9-27] pmol/l) had no significant effect. During gastric lavage at pH 7·0 the median plasma gastrin concentration of the pernicious anaemia patients fell from 320 (63-1760) pmol/l to 125 (46-760) pmol/l (p<0·03). © 1991.
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Publication title
The LancetVolume
338Issue
8764Pagination
410-411ISSN
0140-6736Department/School
College Office - College of Health and MedicinePublisher
Lancet LtdPlace of publication
84 Theobalds Rd, London, England, Wc1X 8RrRepository Status
- Restricted
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