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Hypergastrinaemia: a new mechanism

journal contribution
posted on 2023-05-17, 08:03 authored by Deprez, PH, Ghosh, P, Goodlad, RA, Lacey, SL, Millership, S, Playford, RJ, Lee, CY, Calam, J
The mechanism by which lack of gastric acid causes hypergastrinaemia was investigated in seven patients with pernicious anaemia. Perfusion of gastric juice from the fasting patients (adjusted to pH 7·0) into the stomachs of conscious rats caused a significant rise in plasma gastrin (median 14 [range 2-20] pmol/l to 27 [12-65] pmol/l; p<0·01), whereas perfusion of bicarbonate buffer (18 [13-23] pmol/l to 20 [9-25] pmol/l) or gastric juice from a duodenal ulcer patient (also pH 7·0; 13 [3-30] pmol/l to 17 [9-27] pmol/l) had no significant effect. During gastric lavage at pH 7·0 the median plasma gastrin concentration of the pernicious anaemia patients fell from 320 (63-1760) pmol/l to 125 (46-760) pmol/l (p<0·03). © 1991.

History

Publication title

The Lancet

Volume

338

Issue

8764

Pagination

410-411

ISSN

0140-6736

Department/School

College Office - College of Health and Medicine

Publisher

Lancet Ltd

Place of publication

84 Theobalds Rd, London, England, Wc1X 8Rr

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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