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Hyphenated sample preparation-electrospray and nano-electrospray ionization mass spectrometry for biofluid analysis

journal contribution
posted on 2023-05-21, 10:29 authored by Ibraam MikhailIbraam Mikhail, Tehranirokh, M, Gooley, AA, Rosanne Guijt, Michael BreadmoreMichael Breadmore
Stand-alone electrospray ionization mass spectrometry (ESI-MS) has been advancing through enhancements in throughput, selectivity and sensitivity of mass spectrometers. Unlike traditional MS techniques which usually require extensive offline sample preparation and chromatographic separation, many sample preparation techniques are now directly coupled with stand-alone MS to enable outstanding throughput for bioanalysis. In this review, we summarize the different sample clean-up and/or analyte enrichment strategies that can be directly coupled with ESI-MS and nano-ESI-MS for the analysis of biological fluids. The overview covers the hyphenation of different sample preparation techniques including solid phase extraction (SPE), solid phase micro-extraction (SPME), slug flow micro-extraction/nano-extraction (SFME/SFNE), liquid extraction surface analysis (LESA), extraction electrospray, extraction using digital microfluidics (DMF), and electrokinetic extraction (EkE) with ESI-MS and nano-ESI-MS.

History

Publication title

Journal of Chromatography A

Volume

1646

Article number

462086

Number

462086

Pagination

1-18

ISSN

0021-9673

Department/School

School of Natural Sciences

Publisher

Elsevier Science Bv

Place of publication

Po Box 211, Amsterdam, Netherlands, 1000 Ae

Rights statement

© 2021 Elsevier B.V. All rights reserved

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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