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Hypolipidaemic effect of crude extract from Carpobrotus rossii (pigface) in healthy rats
journal contribution
posted on 2023-05-17, 21:23 authored by Pirie, AD, Noel DaviesNoel Davies, Kiran AhujaKiran Ahuja, Adams, MJ, Shing, CM, Christian NarkowiczChristian Narkowicz, Glenn JacobsonGlenn Jacobson, Dominic GeraghtyCarpobrotus rossii (CR) was used by the Aboriginal population and early European settlers both as a food and therapeutic agent. Based on the presence of flavonoids in CR and results from our previous in vitro investigations, this study aimed to determine whether consumption of CR crude leaf extract: (a) affected lipoprotein profile, resting glucose, systolic blood pressure and vascular function, and (b) produced toxic effects (haematological measures, organ weight) in healthy rats. Male Hooded-Wistar rats (∼230 g) were supplemented for 4 weeks with CR extract in their drinking water (35 mg/kg body weight daily). CR extract produced a significant decrease (18%, p = 0.033) in atherogenic lipoproteins (but not high density lipoprotein). CR supplemented animals showed no signs of haematological toxicity and body and organ weight, daily fluid and food consumption and in vitro vascular responsiveness were similar for both groups. CR also increased (40%, p = 0.049) the renal concentration of 3-hydroxy-3-methylglutaric acid (HMG), consistent with HMG-containing CR flavonoids being bioavailable, and therefore possessing the potential to interfere with cholesterol synthesis pathways. CR extract appears to be safe to ingest and may reduce cardiovascular risk.
History
Publication title
Food and Chemical ToxicologyVolume
66Pagination
134-139ISSN
0278-6915Department/School
School of Pharmacy and PharmacologyPublisher
Pergamon-Elsevier Science LtdPlace of publication
The Boulevard, Langford Lane, Kidlington, Oxford, England, Ox5 1GbRights statement
Copyright 2014 ElsevierRepository Status
- Restricted