Ibandronate in benign bone disease
journal contribution
posted on 2023-05-16, 22:14 authored by Tania WinzenbergTania Winzenberg, Graeme JonesGraeme JonesIbandronate is a potent bisphosphonate which has been most thoroughly assessed in benign bone disease for use in the management of postmenopausal osteoporosis. Its use in corticosteroid-induced osteoporosis, Paget's disease and uncommon benign bone conditions such as localised transient osteoporosis (or bone marrow oedema syndrome) and sternocostoclavicular hyperostosis has also been explored. Recent randomised controlled trial evidence suggests that intermittent high dosage oral ibandronate may be as efficacious as a daily low dose regime for the treatment of post-menopausal osteoporosis, with only a mild increase in adverse events. Movement towards an extended gap between doses has implications for patient compliance and adherence and thus potential benefits for fracture prevention. This review aims to provide an overview of the evidence from randomised controlled trials in humans for the use of ibandronate in benign bone diseases. This includes a discussion of the development program and dosage regimens for the prevention and treatment of postmenopausal osteoporosis, as well as the use of ibandronate in corticosteroid induced osteoporosis, Paget's disease localised transient osteoporosis and sternoclavivular hyperostosis. Adverse effects and long-term safety data will also be reviewed. © 2008 Bentham Science Publishers Ltd.
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Publication title
Reviews on Recent Clinical TrialsPagination
139-149ISSN
1574-8871Department/School
Menzies Institute for Medical ResearchPublisher
Bentham Science Publishers LtdPlace of publication
NetherlandsRepository Status
- Restricted
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