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Identification of Quantitative Trait Loci responsible for embryonic lethality in mice assessed by ultrasonography
journal contribution
posted on 2023-05-17, 02:37 authored by Laissue, P, Burgio, GR, L'Hote, D, Renault, G, Marchiol-Fournigault, C, Fradelizi, D, Fellous, M, Serres, C, Montagutelli, X, Monget, P, Vaiman, DRecurrent Spontaneous Abortion (RSA) is a frequent pathology affecting 1 to 5% of couples. In ∼50 % of cases, the aetiology is unknown suggesting a subtle interaction between genetic and environmental factors. Previous attempts to describe genetic factors using the candidate gene approach have been relatively unsuccessful due to the physiological, cellular and genetic complexity of mammalian reproduction. Indeed, fertility can be considered as a quantitative feature resulting from the interaction of genetic, epigenetic and environmental factors. Herein, we identified Quantitative Trait Loci (QTL) associated with diverse embryonic lethality phenotypes and the subsequent embryonic resorption in 39 inter-specific recombinant congenic mice strains, using in vivo ultrasound bio-microscopy. The short chromosomal intervals related to the phenotypes will facilitate the study of a restricted number of candidate genes which are potentially dysregulated in patients affected by RSA. © 2009 UBC Press.
History
Publication title
The International Journal of Developmental BiologyVolume
53Issue
4Pagination
623-629ISSN
0214-6282Department/School
Menzies Institute for Medical ResearchPublisher
U B C PressPlace of publication
Univ Basque Country, Editorial Services, Po Box 1397, Bilbao, Spain, E-48080Repository Status
- Restricted