University of Tasmania
Browse

File(s) under permanent embargo

Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection

journal contribution
posted on 2023-05-20, 21:03 authored by Gunasegaran KarupiahGunasegaran Karupiah, Chen, J-H, Nathan, CF, Mahalingam, S, MacMicking, JD
To assess whether nitric oxide synthase 2 (NOS2) fulfills the criteria of an innate resistance locus against an acute viral infection, we inoculated genetically deficient NOS2-/- mice with virulent ectromelia virus (EV), the causative agent of mousepox. NOS2-/- mice proved highly susceptible to EV yet showed no diminution in other well-characterized anti-EV immune responses, i.e. , gamma interferon secretion and NK cell and EV-specific cytotoxic T lymphocyte activities. Thus, the NOS2 locus can be considered a critical monogenic determinant of EV resistance that contributes to host survival.

History

Publication title

Journal of Virology

Volume

79

Pagination

7703-7706

ISSN

0022-538X

Department/School

Tasmanian School of Medicine

Publisher

Amer Soc Microbiology

Place of publication

1752 N St Nw, Washington, USA, Dc, 20036-2904

Rights statement

Copyright © 1998, American Society for Microbiology

Repository Status

  • Restricted

Socio-economic Objectives

Prevention of human diseases and conditions; Treatment of human diseases and conditions

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC