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Identifying genetic risk factors for diabetic macular edema and the response to treatment

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journal contribution
posted on 2024-11-12, 00:29 authored by RL Gurung, Liesel FitzgeraldLiesel Fitzgerald, Bennet McComishBennet McComish, Nitin Verma, Kathryn BurdonKathryn Burdon
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus (DM). DR is complex and the term encompasses several clinical subtypes of diabetic eye disease, including diabetic macular edema (DME), the most frequent cause of central vision loss in DR patients. Both genetic and environmental factors contribute to the pathophysiology of DR and its subtypes. While numerous studies have identified several susceptibility genes for DR, few have investigated the impact of genetics on DME susceptibility. This review will focus on the current literature surrounding genetic risk factors associated with DME. We will also highlight the small number of studies investigating the genetics of response to antivascular endothelial growth factor (anti-VEGF) injection, which is used to treat DME.

History

Publication title

Journal of Diabetes Research

Volume

2020

Issue

1

Article number

5016916

Number

5016916

Pagination

1-12

ISSN

2314-6745

Department/School

Medicine, Menzies Institute for Medical Research

Publisher

Hindawi Limited

Publication status

  • Published

Place of publication

United Kingdom

Rights statement

Copyright 2020 Rajya L. Gurung et al. This is an open access article distributed under the Creative Commons Attribution License

Socio-economic Objectives

200101 Diagnosis of human diseases and conditions

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