Identifying genetic risk factors for diabetic macular edema and the response to treatment
journal contributionposted on 2023-05-20, 19:46 authored by Gurung, RL, Liesel FitzgeraldLiesel Fitzgerald, Bennet McComishBennet McComish, Nitin VermaNitin Verma, Kathryn BurdonKathryn Burdon
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus (DM). DR is complex and the term encompasses several clinical subtypes of diabetic eye disease, including diabetic macular edema (DME), the most frequent cause of central vision loss in DR patients. Both genetic and environmental factors contribute to the pathophysiology of DR and its subtypes. While numerous studies have identified several susceptibility genes for DR, few have investigated the impact of genetics on DME susceptibility. This review will focus on the current literature surrounding genetic risk factors associated with DME. We will also highlight the small number of studies investigating the genetics of response to antivascular endothelial growth factor (anti-VEGF) injection, which is used to treat DME.
Publication titleJournal of Diabetes Research
Department/SchoolMenzies Institute for Medical Research
Place of publicationUnited Kingdom
Rights statementCopyright 2020 Rajya L. Gurung et al. This is an open access article distributed under the Creative Commons Attribution License