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Imaging lung tissue oscillations using high-speed X-ray velocimetry

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posted on 2023-05-18, 14:57 authored by Thurgood, J, Dubsky, S, Uesugi, K, Curtis, M, Samarage, CR, Thompson, D, Graeme ZoskyGraeme Zosky, Fouras, A
This work utilized synchrotron imaging to achieve a regional assessment of the lung's response to imparted oscillations. The forced oscillation technique is increasingly being used in clinical and research settings for the measurement of lung function. During the forced oscillation technique, pressure oscillations are imparted to the lungs via the subjects' airway opening and the response is measured. This provides information about the mechanical properties of the airways and lung tissue. The quality of measurements is dependent upon the input signal penetrating uniformly throughout the lung. However, the penetration of these signals is not well understood. The development and use of a novel image-processing technique in conjunction with synchrotron-based imaging was able to regionally assess the lungs' response to input pressure oscillation signals in anaesthetized mice. The imaging-based technique was able to quantify both the power and distribution of lung tissue oscillations during forced oscillations of the lungs. It was observed that under forced oscillations the apices had limited lung tissue expansion relative to the base. This technique could be used to optimize input signals used for the forced oscillation technique or potentially as a diagnostic tool itself.

History

Publication title

Journal of Synchrotron Radiation

Volume

23

Issue

Pt 1

Pagination

324-30

ISSN

0909-0495

Department/School

Tasmanian School of Medicine

Publisher

Blackwell Munksgaard

Place of publication

Denmark

Rights statement

© 2016 International Union of Crystallography

Repository Status

  • Open

Socio-economic Objectives

Expanding knowledge in the environmental sciences

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