University Of Tasmania

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Impact of depression treatment on mental and physical health-related quality of life of cardiac patients: A meta-analysis

journal contribution
posted on 2023-05-17, 06:27 authored by O'Neil, A, Kristy Sanderson, Oldenberg, B, Taylor, CB
PURPOSE: To conduct a meta-analysis evaluating the effectiveness of depression treatment on mental and physical health-related quality of life (HRQOL) of cardiac patients. METHODS: Studies were identified using medical, health, psychiatry, psychology, and social sciences databases. Inclusion criteria were (1) 1 or more control conditions, (2) random assignment to condition after admission for myocardial infarction (MI)(acute coronary syndrome, after recording positive results on a depression screener, (3) documentation of depression symptoms at baseline, (4) depression management as a component of the rehabilitation/intervention, (5) validated measure of HRQOL as an outcome, at minimum 6-month followup. For meta-analysis, mental and physical HRQOL were the end points studied, using standardized mean differences for continuous outcome measures, with 95% confidence intervals. Heterogeneity was explored by calculating I2 statistic. RESULTS: Five randomized controlled trials included in the analysis represented 2105 participants (1058 intervention vs 1047 comparator). Compared with a comparator group at 6 months, a test for overall effect demonstrated statistically significant improvements in mental HRQOL in favor of the intervention (standardized mean differences = -0.29 [-0.38 to -0.20], [P < .00001]; B= 0%). Depression treatment had a modest yet significant impact on physical HRQOL ( standardized mean differences = -0.14 [-0.24 to -0.04] [P - .009]; B= 15%). CONCLUSION: While the impact of post-MI depression interventions on physical HRQOL is modest, treatment can improve mental HRQOL in a significant way. Future research is required to develop and evaluate a program that can achieve vital improvements in overall HRQOL, and potentially cardiovascular outcomes, of cardiac patients.


Publication title

Journal of Cardiopulmonary Rehabilitation and Prevention








Menzies Institute for Medical Research


Lippincott Williams & Wilkins

Place of publication

United States

Rights statement

Copyright © 2011 Lippincott Williams & Wilkins

Repository Status

  • Restricted

Socio-economic Objectives

Mental health