Impaired fasting glucose & 8-iso-prostaglandin F₂ₐ in diabetes disease progression

Aims: The objective of the present study was to evaluate the changes of 8-isoprostaglandin F_2α and other markers of oxidative stress with impaired fasting glucose when compared to non-diabetic control participants.

Methodology: This is a cross-sectional study, conducted at Charles Sturt University, Albury, NSW, Australia and included 428 participants (female: male, 247:181) participants attending the Diabetes Complications Clinic in the School of Community Health for the period between January 2011 to October 2012.

Results: Urinary 8-isoprostaglandin F_2α was significantly greater in the impaired fasting glucose group (1.4 ± 1.3 ng/ml) compared to control group (0.68 ± 0.5 ng/ml, P = .05). The increase in urinary 8-isoprostaglandin F_2α was associated with a significant elevation in serum total cholesterol (4.7 ± 1.1 mol/L, P = .04) and a significant reduction in high density lipoprotein cholesterol (1.4 ± 0.4 mmol/L, P = .02) in the impaired fasting glucose group compared to the control group. A significant negative correlation was noted between urinary 8-isoprostaglandin F_2α and high-density lipoprotein cholesterol among all the participants included in this study (P = .05).

Conclusions: The current study proves the importance of measuring markers of oxidative stress, expressed by urinary 8-isoprostaglandin F_2α and serum lipids in managing cases of impaired fasting glucose and suggests a useful biomarker for assessing disease progression and/or remission, especially in the prediabetic state.