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In-process phase growth measurement technique in the fabrication of monolithic porous layer open tubular (monoPLOT) columns using capacitively coupled contactless conductivity
journal contribution
posted on 2023-05-17, 17:57 authored by Collins, DA, Nesterenko, EP, Brabazon, D, Brett PaullBrett PaullA technique for the in-process measurement of polymer stationary phase growth inside fused silica capillaries during the fabrication of monolithic porous layer open tubular (monoPLOT) columns is presented. In this work, capacitively coupled contactless conductivity detection (C4D) was applied as an online measurement tool for porous polymer layer growth within fused silica capillaries. The relationship between effective capillary diameter and C4D response was investigated for two polymers, butyl methacrylate–ethylene dimethacrylate (BuMA–EDMA) and polystyrene–divinylbenzene (PS–DVB) over a range of capillary diameters and layer thicknesses. The described technique can be used with both thermal and photo-initiated approaches for monoPLOT fabrication and provides an accurate, real-time measurement of the porous layer growth within the capillary, which should vastly improve column-to-column reproducibility. The technique was shown to be very precise, with a measured %RSD < 10%.
History
Publication title
The AnalystVolume
138Issue
9Pagination
2540-2545ISSN
0003-2654Department/School
School of Natural SciencesPublisher
RSC PublicationsPlace of publication
United KingdomRights statement
Copyright 2013 The Royal Society of ChemistryRepository Status
- Restricted