University Of Tasmania

File(s) under permanent embargo

Infant anthropometry, early life infection, and subsequent risk of type 1 diabetes mellitus: a prospective birth cohort study

journal contribution
posted on 2023-05-17, 12:05 authored by Ponsonby, AL, Pezic, A, Jennifer Cochrane, Cameron, FJ, Pascoe, M, Kemp, A, Terry DwyerTerry Dwyer
Background: Higher birthweight is associated with increased type 1 diabetes mellitus (T1DM) risk, but the contribution of higher adiposity or lean mass is unclear. In this Tasmanian infant cohort, early upper respiratory infection has been associated with higher asthma risk. Patients and methods: Eligible infants represented one-fifth of live births in Tasmania, 1988–1995. Hospital interview data (day 6) were obtained on 96.3% (10 628/11 040), home (5 wk) visit data (38 d) on 92.9% (9876/10 628) of those, then a phone (12 wk) interview (87 d). Tricep and subscapular skinfold measures and upper arm circumference were recorded at the first two interviews. T1DM cases (n = 26) arising from the age of 16 or under in Tasmania from 1988 to 2006 were ascertained. Results: Higher birthweight [adjusted odds ratio (AOR) 2.82 (95% CI 1.31–6.09)], lean mid-upper arm circumference [AOR 1.76 (95% CI 1.16–2.66)], not skinfold measures, were associated with T1DM risk. Children with an early upper respiratory tract infection by 5-wk visit [AOR 2.74 (95% CI 1.19–6.32)] or ear infection by 12-wk interview [AOR 3.44 (95% CI 1.00–11.79)] were also at higher risk. Putative markers of altered microbial exposure such as resident density were not associated with T1DM risk but the effect of increasing birth order on T1DM risk differed for older (AOR 0.41, p = 0.02) than young mother (AOR 2.45, p = 0.01); difference in effect, p = 0.001. Conclusion: In this cohort, early upper respiratory tract infection was associated with T1DM risk, as had been previously found for asthma, consistent with immunoinflammatory upregulation. Using the detailed anthropometric measures available, the link between higher birthweight and T1DM did not appear to reflect increased adiposity.


Publication title

Pediatric Diabetes










Menzies Institute for Medical Research


Wiley-Blackwell Publishing, Inc.

Place of publication


Rights statement

Copyright 2011 John Wiley & Sons A/S

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania