149248 - Insulin resistance in the brain.pdf (1.94 MB)
Insulin resistance in the brain: Evidence supporting a role for inflammation, reactive microglia, and the impact of biological sex
journal contribution
posted on 2023-05-21, 06:28 authored by Yasmine DoustYasmine Doust, Nicole SumargoNicole Sumargo, Jenna ZiebellJenna Ziebell, Dino PremilovacDino PremilovacIncreased intake of highly processed, energy-dense foods combined with a sedentary lifestyle are helping fuel the current overweight and obesity crisis, which is more prevalent in women than in men. Although peripheral organs such as adipose tissue contribute to the physiological development of obesity, emerging work aims to understand the role of the central nervous system to whole body energy homeostasis and development of weight gain and obesity. The present review discusses the impact of insulin, insulin resistance, free fatty acids, and inflammation on brain function and how these differ between the males and females in the context of obesity. We highlight the potential of microglia, the resident immune cells in the brain, as mediators of neuronal insulin resistance that drive reduced satiety, increased food intake and thus, obesity.
History
Publication title
NeuroendocrinologyPagination
1-12ISSN
0028-3835Department/School
Wicking Dementia Research Education CentrePublisher
KargerPlace of publication
Allschwilerstrasse 10, Basel, Switzerland, Ch-4009Rights statement
Copyright 2022 S. Karger AG, BaselRepository Status
- Open