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Integrating muscle cell biochemistry and whole-body physiology in humans: 31P-MRS data from the InSight trial

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posted on 2023-05-17, 16:27 authored by Edwards, LM, Kemp, GJ, Renee RossRenee Ross, Justin WallsJustin Walls, Fuller, HJ, Smith, SR, Earnest, CP
We acquired 31P-MRS data from skeletal muscle of subjects of mixed gender and ethnicity, combined with a panel of physiological characteristics, and tested several long-standing hypotheses regarding relationships between muscle cell biochemistry and whole-body physiology with unusually high statistical power. We hypothesized that i) whole-body VO2max would correlate with muscle respiratory capacity, ii) resting muscle phosphocreatine concentration ([PCr]) would negatively correlate with delta efficiency and iii) muscle mitochondrial function would positively correlate with both resting VO2 and total daily energy expenditure (TDEE). Muscle respiratory capacity explained a quarter of the variation in VO2max (r2 = 26, p < .001, n = 87). There was an inverse correlation between muscle [PCr] and delta efficiency (r = −23, p = 046, n = 87). There was also a correlation between [PCr] recovery halftime and TDEE (r = −23, p = 035, n = 87). Our data not only provide insights into muscle cell chemistry and whole-body physiology but our mixed cohort means that our findings are broadly generalizable.

History

Publication title

Scientific Reports

Article number

1182

Number

1182

Pagination

1-7

ISSN

2045-2322

Department/School

Tasmanian School of Medicine

Publisher

Nature Publishing Group

Place of publication

England

Rights statement

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. http://creativecommons.org/licenses/by-nc-nd/3.0/

Repository Status

  • Open

Socio-economic Objectives

Expanding knowledge in the health sciences

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