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Interferon-inducible chemokines and immunity to poxvirus infections

journal contribution
posted on 2023-05-23, 00:00 authored by Mahalingam, S, Foster, PS, Lobigs, M, Farber, JM, Gunasegaran KarupiahGunasegaran Karupiah
The biological roles of two interferon-inducible chemokines, monokine induced by gamma interferon (Mig) and cytokine responsive gene (Crg-2), in the immune response against vaccinia virus (VV) and ectromelia virus (EV) infections are discussed. To investigate their antiviral effects in vivo, the expression profiles of these chemokines during the course of VV or EV infections were first established. Mig and Crg-2 were induced in multiple organs at high levels early after infection with VV. Both chemokines were rapidly induced in popliteal lymph nodes of C57BL/6 mice but not in BALB/c mice following infection with EV. Secondly, recombinant vaccinia viruses (rVV) encoding Mig or Crg-2 were constructed to investigate the immunobiology of infection in athymic, nude and euthymic, normal mice. Finally, the EV model in combination with recombinant Mig and Crg-2 proteins was used to test their effects on viral replication and immune responses in vivo. The results of these investigations demonstrate that the mechanisms of Mig- and Crg-2-induced viral clearance involve natural killer cells and interferons.

History

Publication title

Immunological Reviews

Volume

177

Pagination

127-33

ISSN

0105-2896

Department/School

Tasmanian School of Medicine

Publisher

Blackwell Munksgaard

Place of publication

35 Norre Sogade, Po Box 2148, Copenhagen, Denmark, Dk-1016

Repository Status

  • Restricted

Socio-economic Objectives

Prevention of human diseases and conditions; Treatment of human diseases and conditions

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