Interhemispheric connectivity between distinct motor regions as a window into bimanual coordination

Performing coordinated bimanual movement is a fundamental feature of the human motor system, with imaging techniques revealing the involvement of an extensive network of motor regions in both hemispheres. Using transcranial magnetic stimulation, Liuzzi et al. (J Neurosci 31: 9111-9117, 2011) recently extended our understanding of the neural correlates of motor actions by showing that the nature of the interhemispheric connectivity between primary and premotor regions may influence motor performance during a bimanual tapping task. © 2012 the American Physiological Society.