University Of Tasmania

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Interleukin-13: A pivotal target against influenza-induced exacerbation of chronic lung diseases

journal contribution
posted on 2023-05-21, 01:35 authored by Madhur ShastriMadhur Shastri, Allam, VSRR, Shukla, SD, Jha, NK, Paudel, KR, Gregory PetersonGregory Peterson, Rahul PatelRahul Patel, Hansbro, PM, Chellappan, DK, Dua, K
Non-communicable, chronic respiratory diseases (CRDs) affect millions of individuals worldwide. The course of these CRDs (asthma, chronic obstructive pulmonary disease, and cystic fibrosis) are often punctuated by microbial infections that may result in hospitalization and are associated with increased risk of morbidity and mortality, as well as reduced quality of life. Interleukin-13 (IL-13) is a key protein that regulates airway inflammation and mucus hypersecretion. There has been much interest in IL-13 from the last two decades. This cytokine is believed to play a decisive role in the exacerbation of inflammation during the course of viral infections, especially, in those with pre-existing CRDs. Here, we discuss the common viral infections in CRDs, as well as the potential role that IL-13 plays in the virus-induced disease pathogenesis of CRDs. We also discuss, in detail, the immune-modulation potential of IL-13 that could be translated to in-depth studies to develop IL-13-based therapeutic entities.


Publication title

Life Sciences








School of Pharmacy and Pharmacology


Pergamon-Elsevier Science Ltd

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Treatment of human diseases and conditions