University Of Tasmania

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Is Lactobacillus rhamnosus GG effective in preventing the onset of antibiotic-associated diarrhoea: a systematic review

journal contribution
posted on 2023-05-18, 05:00 authored by Jason Hawrelak, Whitten, DL, Myers, SP

OBJECTIVE: To evaluate the efficacy of Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea.

DATA SOURCES: A computer-based search of MEDLINE, CINAHL, AMED, the Cochrane Controlled Trials Register and the Cochrane Database of Systematic Reviews was conducted. A hand-search of the bibliographies of relevant papers and previous meta-analyses was undertaken.

REVIEW METHODS: Trials were included in the review if they compared the effects of L. rhamnosus GG and placebo and listed diarrhoea as a primary end-point. Studies were excluded if they were not placebo-controlled or utilised other probiotic strains.

RESULTS: Six trials were found that met all eligibility requirements. Significant statistical heterogeneity of the trials precluded meta-analysis. Four of the six trials found a significant reduction in the risk of antibiotic-associated diarrhoea with co-administration of Lactobacillus GG. One of the trials found a reduced number of days with antibiotic-induced diarrhoea with Lactobacillus GG administration, whilst the final trial found no benefit of Lactobacillus GG supplementation.

CONCLUSION: Additional research is needed to further clarify the effectiveness of Lactobacillus GG in the prevention of antibiotic-associated diarrhoea.


Publication title

Digestion: International Journal of Gastroenterology








School of Pharmacy and Pharmacology



Place of publication

Allschwilerstrasse 10, Basel, Switzerland, Ch-4009

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the health sciences