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Is metformin use associated with a reduced risk of oesophageal cancer? A systematic review and meta-analysis

journal contribution
posted on 2023-05-21, 02:53 authored by Chen, Y, Cheng, X, Sun, C, Kim, NH, Kailas, S, Qureshi, F, Karadsheh, Z, Wu, Y, Hu, L, Zhen ZhouZhen Zhou, Bhan, C, Kim, KY, Manem, R, Cheng, C, Zhou, Q

Objectives: Studies on the association between metformin use and the risk of oesophageal cancer (OC) have generated controversial findings. This updated meta-analysis was conducted to reassess the effects of metformin on OC.

Methods: A comprehensive search strategy was conducted to select relevant studies from origination to February 2021. Heterogeneity was evaluated through the Q test and I2 statistics. HRs and 95% CIs were pooled through either random-effect or fixed-effect models. Meta-regression, subgroup analyses, sensitivity analysis and publication bias diagnosis were also performed.

Results: Seven studies with 5 426 343 subjects were included. Metformin use was associated with reduced risk of OC (HR=0.69, 95% CI 0.54 to 0.87, p<0.001). Sensitivity analysis suggested that the results were relatively stable.

Conclusion: Metformin is associated with a reduced risk of OC. More well-designed studies are still needed to further elaborate on these associations.


Publication title

Postgraduate Medical Journal






Menzies Institute for Medical Research


B M J Publishing Group

Place of publication

British Med Assoc House, Tavistock Square, London, England, Wc1H 9Jr

Rights statement

© Author(s) (or their employer(s)) 2021.

Repository Status

  • Restricted

Socio-economic Objectives

Efficacy of medications

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