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Islet Cell Transplantation in Australia: Screening, Remote Transplantation, and Incretin Hormone Secretion in Insulin Independent Patients

journal contribution
posted on 2023-05-18, 05:47 authored by Marathe, CS, Drogemuller, CJ, Marathe, JA, Louavaris, T, Hawthorne, WJ, O'Connell, PJ, Radford, T, Kay, TW, Horowitz, M, Coates, PT, Tropy, DJ
Islet cell transplantation has emerged as a treatment modality for type 1 diabetes in the last 15 years due to the Edmonton protocol leading to consistent and sustained exogenous insulin independence post-transplantation. In recent years, consortia that involve both local and remote islet cell centers have been established, with local centers responsible for processing and shipping of islet cells, and remote centers only transplanting them. There are, however, few data on patient outcomes at remote centers. A tendency for high fasting glucose despite insulin independence was noted by us and others with an unknown mechanism. This review provides a brief history of islet cell transplantation, and focuses on the South Australian remote center experience: the challenges, screening criteria, and the impact on incretin hormone secretion of insulin independent transplant patients.

History

Publication title

Hormone and Metabolic Research

ISSN

0018-5043

Department/School

Tasmanian School of Medicine

Publisher

Georg Thieme Verlag Kg

Place of publication

Rudigerstr 14, Stuttgart, Germany, D-70469

Rights statement

Copyright 2015 Georg Thieme Verlag

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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