Thornton 2010.pdf (198 kB)
Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury
journal contributionposted on 2023-05-18, 11:38 authored by Thornton, E, Ziebell, JM, Leonard, AV, Vink, R
Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and substance P. These neuropeptides are known to have a potent pro-inflammatory role and can initiate neurogenic inflammation resulting in vasodilation, plasma extravasation and the subsequent development of edema. As inflammation and edema play an integral role in the progressive secondary injury that causes neurological deficits, this review critically examines kinin receptor antagonists as a potential neuroprotective intervention for acute brain injury, and more specifically, traumatic brain and spinal cord injury and stroke.
Publication titleMolecules: A Journal of Synthetic Organic and Natural Product Chemistry
PublisherMolecular Diversity Preservation International
Place of publicationSwitzerland
Rights statementCopyright 2010 The Authors Licenced under the Creative Commons Attribution license 3.0 http://creativecommons.org/licenses/by/3.0/