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Last hope for the doomed? Thoughts on the importance of a parasexual cycle for the yeast Candida albicans

journal contribution
posted on 2023-05-18, 12:53 authored by Schmid, J, Magee, PT, Barbara HollandBarbara Holland, Zhang, N, Cannon, RD, Magee, BB
The yeast Candida albicans, a commensal colonizer and occasional pathogen of humans, has a rudimentary mating ability. However, mating is a cumbersome process that has never been observed outside the laboratory, and the population structure of the species is predominantly clonal. Here we discuss recent findings that indicate that mating ability is under selection in C. albicans, i.e. that it is a biologically relevant process. C. albicans strains can only mate after they have sustained genetic damage. We propose that the rescue of such damaged strains by mating may be the primary reason why mating ability is under selection.

History

Publication title

Current Genetics

Volume

62

Pagination

81-85

ISSN

0172-8083

Department/School

School of Natural Sciences

Publisher

Springer

Place of publication

New York, USA

Rights statement

Copyright 2015 Springer-Verlag Berlin Heidelberg

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the biological sciences

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