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Leishmaniasis host response loci (Imr1-3) modify disease severity through a Th1/Th2-independent pathway
journal contribution
posted on 2023-05-16, 16:47 authored by Elso, CM, Roberts, LJ, Smyth, GK, Russell Thomson, Baldwin, TM, Simon James FooteSimon James Foote, Handman, EThe severity of disease caused by infection with Leishmania major depends critically on the genetics of the host. Early induction of T helper (Th) 1-type immune responses in the resistant C57BL/6 mice and Th2-type responses in the susceptible BALB/c mice are thought to determine cure or disease, respectively. We have previously mapped three host response loci in a genetic cross between C57BL/6 and BALB/c mice, and here we show definitively the involvement of these loci in disease severity using animals congenic for each of the loci. Surprisingly, in the late stage of infection when the difference in disease severity between congenic and parental mice was most pronounced, their cytokine profile correlated with the genetic background of the mice and not with the severity of disease. This indicates that the loci that we have mapped are acting by a mechanism independent of Th phenotype. © 2004 Nature Publishing Group All rights reserved.
History
Publication title
Genes and ImmunityVolume
5Pagination
93-100ISSN
1466-4879Department/School
Menzies Institute for Medical ResearchPublisher
Nature Publishing GroupPlace of publication
USARepository Status
- Restricted