File(s) under permanent embargo
Lipase-catalyzed Irreversible Transesterification of Secondary Alcohols Using Isopropenyl Acetate
journal contributionposted on 2023-05-17, 00:14 authored by Ghanem, A, Schurig, V
Asymmetric acetylation of a set of secondary alcohols with the innocuous acyl donor isopropenyl acetate catalyzed by a lipase from Pseudomonas cepacia immobilized on ceramic particles (PSL-C) in toluene as organic medium afforded the chiral alcohols and the corresponding acetates in high enantiomeric excess (up to 99%). An effective baseline separation of the enantiomers of both substrate and product was performed in one analysis without derivatization using gas chromatography on a new chiral stationary phase (CSP) Chirasil-beta-Dex containing an undecamethylene spacer (C11-Chirasil-Dex).
Publication titleMonatshefte für Chemie / Chemical Monthly
Department/SchoolSchool of Natural Sciences
Place of publicationSachsenplatz 4-6, Po Box 89, Vienna, Austria, A-12
Rights statementThe original publication is available at www.springerlink.com