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Lipase-catalyzed irreversible transesterification of 1-(2-furyl)ethanol using isopropenyl acetate
journal contribution
posted on 2023-05-16, 23:59 authored by Ghanem, A, Schurig, VAsymmetric acetylation of racemic 1-(2-furyl)ethanol with the innocuous acyl donor isopropenyl acetate catalyzed by lipases in organic media afforded the chiral alcohol and acetate in high enantiomeric excess (up to 99%). The effect of molecular sieves as well as organic solvents on the kinetic resolution were studied. An effective separation of the enantiomers of both substrate and product was performed using gas chromatography on the chiral stationary phase heptakis-(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)--cyclodextrin.
History
Publication title
ChiralityVolume
13Pagination
118-123ISSN
0899-0042Department/School
School of Natural SciencesPublisher
WileyPlace of publication
GermanyRights statement
The definitive published version is available online at: http://interscience.wiley.comRepository Status
- Restricted