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Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice
journal contribution
posted on 2023-05-20, 11:04 authored by Wang, S, Ahmadi, S, Nagpal, R, Jain, S, Mishra, SP, Kylie KavanaghKylie Kavanagh, Zhu, X, Wang, Z, McClain, DA, Kritchevsky, SB, Kitzman, DW, Yadav, HIncreased inflammation associated with leaky gut is a major risk factor for morbidity and mortality in older adults; however, successful preventive and therapeutic strategies against these conditions are not available. In this study, we demonstrate that a human-origin Lactobacillus paracasei D3-5 strain (D3-5), even in the non-viable form, extends life span of Caenorhabditis elegans. In addition, feeding of heat-killed D3-5 to old mice (> 79 weeks) prevents high- fat diet-induced metabolic dysfunctions, decreases leaky gut and inflammation, and improves physical and cognitive functions. D3-5 feeding significantly increases mucin production, and proportionately, the abundance of mucin-degrading bacteria Akkermansia muciniphila also increases. Mechanistically, we show that the lipoteichoic acid (LTA), a cell wall component of D3-5, enhances mucin (Muc2) expression by modulating TLR-2/p38-MAPK/NF-kB pathway, which in turn reduces age-related leaky gut and inflammation. The findings indicate that the D3-5 and its LTA can prevent/treat age-related leaky gut and inflammation.
History
Publication title
GeroScienceVolume
42Pagination
.333-352ISSN
2509-2715Department/School
Tasmanian School of MedicinePublisher
Springer International PublishingPlace of publication
SwitzerlandRights statement
Copyright 2019 American Aging AssociationRepository Status
- Restricted