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129906 - MRI-detected osteophytes of the knee.pdf (2.02 MB)
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MRI-detected osteophytes of the knee: natural history and structural correlates of change

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journal contribution
posted on 2023-05-19, 23:28 authored by Zhu, Z, Chang-Hai DingChang-Hai Ding, Han, W, Zheng, S, Tania WinzenbergTania Winzenberg, Cicuttini, F, Graeme JonesGraeme Jones
Background: The natural history of semi-quantitative magnetic resonance imaging (MRI)-detected osteophytes (MRI-detected OPs) has not been described and it is unknown whether knee structural abnormalities can predict MRI-detected OP change over time. Thus, the aim of current study is to describe the natural history of knee MRI-detected OP, and to determine if knee structural abnormalities are associated with change of MRI-detected OP in a longitudinal study of older adults.

Methods: Randomly selected older adults (n = 837, mean age 63 years) had MRI at baseline and 413 of them had MRI 2.6 years later to measure MRI-detected OP, cartilage defects, cartilage volume, bone marrow lesions (BMLs), meniscal extrusion, infrapatellar fat pad (IPFP) quality score/maximum area and effusion-synovitis.

Results: Over 2.6 years, average MRI-detected OP score increased significantly in all compartments. The total MRI-detected OP score remained stable in 53% of participants, worsened (≥ 1-point increase) in 46% and decreased in 1%. Baseline cartilage defects (RR, 1.25-1.35), BMLs (RR, 1.16-1.17), meniscal extrusion (RR, 1.22-1.33) and IPFP quality score (RR, 1.08-1.20) site-specifically and independently predicted an increase in MRI-detected OP (p values all ≤ 0.05), after adjustment for covariates. Presence of IPFP abnormality was significantly associated with increased MRI-detected OPs but became non-significant after adjustment for other structural abnormalities. Total (RR, 1.27) and suprapatellar pouch effusion-synovitis (RR, 1.22) were both associated with increased MRI-detected OPs in the lateral compartment only (both p < 0.04).

Conclusion: Knee MRI-detected OPs are common in older adults and are likely to progress. The association between baseline structural abnormalities and worsening MRI-detected OPs suggest MRI-detected OP could be a consequence of multiple knee structural abnormalities.


Publication title

Arthritis Research & Therapy



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Menzies Institute for Medical Research


Biomed Central Ltd

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Middlesex House, 34-42 Cleveland St, London, England, W1T 4Lb

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Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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