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Mapping of the Plasmodium chabaudi Resistance Locus Char2

Version 2 2024-09-17, 02:03
Version 1 2023-05-16, 18:41
journal contribution
posted on 2024-09-17, 02:03 authored by E Lin, T Pappenfuss, RB Tan, D Senyschyn, M Bahlo, TP Speed, Simon James FooteSimon James Foote
Animals congenic for the char2 host response locus to the murine malarial parasite Plasmodium chabaudi have been bred, and they demonstrated a phenotypic difference from the parental lines. These congenic lines have been crossed back to the parental line to generate recombinants across the congenic intervals. The recombinants were inbred, and the subcongenic intervals were fixed. These lines were then challenged with parasites and assessed as being either resistant or susceptible. From the analysis of many subcongenic lines, it has become obvious that there are at least two loci underlying the char2 locus and that both of these mediate resistance when the haplotype derives from the resistant C57BL/6 strain. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

History

Publication title

Infection and Immunity

Volume

74

Issue

10

Pagination

5814-5819

ISSN

0019-9567

Department/School

Menzies Institute for Medical Research

Publisher

American Society for Microbiology

Publication status

  • Published

Place of publication

United States

Socio-economic Objectives

200199 Clinical health not elsewhere classified

UN Sustainable Development Goals

3 Good Health and Well Being

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