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Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis
journal contribution
posted on 2023-05-17, 05:35 authored by Jastroch, M, Withers, KW, Taudien, S, Peter FrappellPeter Frappell, Helwig, M, Fromme, T, Hirschberg, V, Heldmaier, G, McAllan, BM, Firth, BT, Burmester, T, Platzer, M, Klingenspor, MBrown adipose tissue expressing uncoupling protein 1 (UCP1) is responsible for adaptive nonshivering thermogenesis giving eutherian mammals crucial advantage to survive the cold. The emergence of this thermogenic organ during mammalian evolution remained unknown as the identification of UCP1 in marsupials failed so far. Here, we unequivocally identify the marsupial UCP1 ortholog in a genomic library of Monodelphis domestica. In South American and Australian marsupials, UCP1 is exclusively expressed in distinct adipose tissue sites and appears to be recruited by cold exposure in the smallest species under investigation (Sminthopsis crassicaudata). Our data suggest that an archetypal brown adipose tissue was present at least 150 million yr ago allowing early mammals to produce endogenous heat in the cold, without dependence on shivering and locomotor activity.
History
Publication title
Physiological GenomicsVolume
32Pagination
161-169ISSN
1094-8341Department/School
School of Natural SciencesPublisher
Amer Physiological SocPlace of publication
9650 Rockville Pike, Bethesda, USA, Md, 20814Rights statement
Copyright © 2011 the American Physiological SocietyRepository Status
- Restricted