dePaoli et al 2017.pdf (1.92 MB)
Download fileMeasuring animal age with DNA methylation: from humans to wild animals
journal contribution
posted on 2023-05-19, 11:25 authored by De Paoli-Iseppi, R, Bruce Deagle, McMahon, CR, Mark HindellMark Hindell, Joanne DickinsonJoanne Dickinson, Jarman, SNDNA methylation (DNAm) is a key mechanism for regulating gene expression in animals and levels are known to change with age. Recent studies have used DNAm changes as a biomarker to estimate chronological age in humans and these techniques are now also being applied to domestic and wild animals. Animal age is widely used to track ongoing changes in ecosystems, however chronological age information is often unavailable for wild animals. An ability to estimate age would lead to improved monitoring of (i) population trends and status and (ii) demographic properties such as age structure and reproductive performance. Recent studies have revealed new examples of DNAm age association in several new species increasing the potential for developing DNAm age biomarkers for a broad range of wild animals. Emerging technologies for measuring DNAm will also enhance our ability to study age-related DNAm changes and to develop new molecular age biomarkers.
History
Publication title
Frontiers in GeneticsVolume
8Article number
106Number
106Pagination
1-8ISSN
1664-8021Department/School
Institute for Marine and Antarctic StudiesPublisher
Frontiers Research FoundationPlace of publication
SwitzerlandRights statement
Copyright 2017 De Paoli-Iseppi, Deagle, McMahon, Hindell, Dickinson and Jarman. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/Repository Status
- Open