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Measuring the interaction between the macro- and micro-vasculature

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posted on 2023-05-20, 08:59 authored by Rachel ClimieRachel Climie, Gallo, A, Dean PiconeDean Picone, Di Lascio, N, van Sloten, TT, Guala, A, Mayer, CC, Hametner, B, Bruno, RM
Structural and functional dysfunction in both the macro- and microvasculature are a feature of essential hypertension. In a healthy cardiovascular system, the elastic properties of the large arteries ensure that pulsations in pressure and flow generated by cyclic left ventricular contraction are dampened, so that less pulsatile pressure and flow are delivered at the microvascular level. However, in response to aging, hypertension, and other disease states, arterial stiffening limits the buffering capacity of the elastic arteries, thus exposing the microvasculature to increased pulsatile stress. This is thought to be particularly pertinent to high flow/low resistance organs such as the brain and kidney, which may be sensitive to excess pressure and flow pulsatility, damaging capillary networks, and resulting in target organ damage. In this review, we describe the clinical relevance of the pulsatile interaction between the macro- and microvasculature and summarize current methods for measuring the transmission of pulsatility between the two sites.

History

Publication title

Frontiers in Cardiovascular Medicine

Volume

6

Article number

169

Number

169

Pagination

1-15

ISSN

2297-055X

Department/School

Menzies Institute for Medical Research

Publisher

Frontiers Research Foundation

Place of publication

Switzerland

Rights statement

Copyright © 2019 Climie, Gallo, Picone, Di Lascio, van Sloten, Guala, Mayer, Hametner and Bruno. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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