137836 - Medication adherence burden.pdf (619.68 kB)
Download fileMedication adherence, burden and health-related quality of life in adults with predialysis chronic kidney disease: A prospective cohort study
journal contribution
posted on 2023-05-20, 11:38 authored by Tesfaye, WH, Charlotte McKercher, Gregory PetersonGregory Peterson, Ronald CastelinoRonald Castelino, Matthew JoseMatthew Jose, Syed Razi ZaidiSyed Razi Zaidi, Barbara WimmerThis study examines the associations between medication adherence and burden, and health-related quality of life (HRQOL) in predialysis chronic kidney disease (CKD). A prospective study targeting adults with advanced CKD (estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2) and not receiving renal replacement therapy was conducted in Tasmania, Australia. The actual medication burden was assessed using the 65-item Medication Regimen Complexity Index, whereas perceived burden was self-reported using a brief validated questionnaire. Medication adherence was assessed using a four-item Morisky-Green-Levine Scale (MGLS) and the Tool for Adherence Behaviour Screening (TABS). The Kidney Disease and Quality of Life Short-Form was used to assess HRQOL. Of 464 eligible adults, 101 participated in the baseline interview and 63 completed a follow-up interview at around 14 months. Participants were predominantly men (67%), with a mean age of 72 (SD 11) years and eGFR of 21 (SD 6) mL/min/1.73 m2. Overall, 43% and 60% of participants reported medication nonadherence based on MGLS and TABS, respectively. Higher perceived medication burden and desire for decision-making were associated with nonadherent behaviour. Poorer HRQOL was associated with higher regimen complexity, whereas nonadherence was associated with a decline in physical HRQOL over time. Medication nonadherence, driven by perceived medication burden, was prevalent in this cohort, and was associated with a decline in physical HRQOL over time.
History
Publication title
International Journal of Environmental Research and Public HealthVolume
17Article number
371Number
371Pagination
1-13ISSN
1660-4601Department/School
School of Pharmacy and PharmacologyPublisher
MDPIPlace of publication
SwitzerlandRights statement
Copyright 2020 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/Repository Status
- Open