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Metabolic controls in precancerous liver: defective control of cholesterol synthesis in rats fed N-2-fluorenylacetamide
journal contributionposted on 2023-05-17, 02:30 authored by Brian HortonBrian Horton, Sabine, JR
We have measured synthesis of cholesterol from 14C-acetate in liver slices rats fed the hepatocarcinogen, N-2-fluorenylacetamide (FAA). Within 2-3 weeks of beginning FAA feeding (a) cholesterol synthesis was increased (b) feedback control of cholesterogenesis was partially or completely lost, (c) cholesterol synthesis was extremely variable within all groups fed FAA. Feedback control was regained within 16 weeks in the liver, but remained defective in the hyperplastic nodules present on some livers at that time. The study of such precancerous livers should prove useful in understanding both the mechanism of lost metabolic control shown by fully-developed hepatomas, and the relationships between loss of control and the neoplastic process. Â© 1971.
Publication titleEuropean Journal of Cancer
Department/SchoolTasmanian Institute of Agriculture (TIA)
PublisherPergamon-Elsevier Science Ltd
Place of publicationThe Boulevard, Langford Lane, Kidlington, Oxford, England, Ox5 1Gb