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Metabolomics as a functional tool in screening gastro intestinal diseases: Where are we in High Throughput Screening?

journal contribution
posted on 2023-05-21, 12:32 authored by Gundamaraju, R, Vemuri, R, Rajaraman Eri, Ishiki, HM, Coy-Barrera, E, Yarla, NS, Dos Santos, SG, Alves, MF, Filho, JMB, Diniz, MFFM, Scotti, MT, Scotti, L
Identifying novel bio markers in gastro intestinal disease is a promising method where a comprehensive analysis of the metabolome is performed. Metabolomics has evolved enormously in the past decade, paving a path in gastro intestinal disease research, especially diseases which lead to high morbidity and mortality. Metabolomics involves identifying metabolites such as anti-oxidants, and amino acids etc., which are screened in the urine, feces and tissue samples. Certain cases employ advanced tools like GC-MS, 1HNMR and GC-MS/SPME which reveal valuable information concerning disease severity and differentiation. In light of escalating health care costs and risky invasive procedures, metabolomics can be chosen as a safe yet precise method for screening diseases like ulcerative colitis, Crohns' disease, celiac disease, and gastro intestinal cancers. The present review focuses on major advancements in gastro intestinal metabolomics, giving attention to which parameters are assessed, and to recent changes in metabolite analysis.

History

Publication title

Combinatorial Chemistry and High Throughput Screening

Volume

20

Pagination

247-254

ISSN

1386-2073

Department/School

School of Health Sciences

Publisher

Bentham Science Publ Ltd

Place of publication

Po Box 1673, Hilversum, Netherlands, 1200 Br

Repository Status

  • Restricted

Socio-economic Objectives

Treatment of human diseases and conditions

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