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Metallothionein biology in the ageing and neurodegenerative brain

journal contribution
posted on 2023-05-16, 17:28 authored by Dittman, J, Fung, SJ, James VickersJames Vickers, Meng Inn ChuahMeng Inn Chuah, Chung, RS, Adrian WestAdrian West
In recent years metallothionein (MT) biology has moved from investigation of its ability to protect against environmental heavy metals to a wider appreciation of its role in responding to cellular stress, whether as a consequence of normal function, or following injury and disease. This is exemplified by recent investigation of MT in the mammalian brain where plausible roles for MT action have been described, including zinc metabolism, free radical scavenging, and protection and regeneration following neurological injury. Along with other laboratories we have used several models of central nervous system (CNS) injury to investigate possible parallels between injury-dependent changes in MT expression and those observed in the ageing and/or degenerating brain. Therefore, this brief review aims to summarise existing information on MT expression during CNS ageing, and to examine the possible involvement of this protein in the course of human neurodegenerative disease, as exemplified by Alzheimer's disease. © Springer 2005.

History

Publication title

Neurotoxicity Research

Volume

7

Issue

1, 2

Pagination

87-93

ISSN

1029-8428

Department/School

Tasmanian School of Medicine

Publisher

FP Graham Publishing Co

Place of publication

USA

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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