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Methylmercury(II) sulfhydryl interactions. Potentiometric determination of the formation constants for complexation of methylmercury(II) by sulfhydryl containing amino acids and related molecules, including glutathione
journal contributionposted on 2023-05-26, 16:00 authored by Arnold, AP, Canty, AJ
The interaction of methylmercury with thiols to form methylmercury thiolate complexes MeHgSR is believed to be important in both the toxicology of methylmercury and the use of antidotes for mercury poisoning containing thiol groups. Thus, a fundamental requirement in studying the biological behaviour of methylmercury is accurate values of equilibrium constants for these interactions. Formation constants for the interaction of mcthylmercury(II) with 2-mercaptoethanol. mercaptoacetic acid. O-methylmercaptoacetate. 2-mercaptosuccinic acid. L-cystcinc, D,L-penicillamine. N-acetyl-D,L-penicillamine, glutathione, thiocholine. and 4-mercapto-N-methylpiperidine have been dctcnnincd by potentiometric titratiun. Acid dissociation constants for the ligands are reported. Formation constants for the addition of both one and two equivalents of methylmercury to L-cysteine have been determined.
Publication titleCanadian Journal of Chemistry
Rights statementCopyright 1983. National Research Council. Please refer to the journal link for access to the definitive, published version. Under the Canadian Copyright Act, individuals may download or print single copies of articles for personal research or study. Any person may reproduce short excerpts from articles in the journals for any purpose that respects the moral rights of authors, provided that the source is fully acknowledged. As a courtesy, the consent of authors of such material should be obtained directly from the author.