Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems
journal contribution
posted on 2023-05-20, 18:38 authored by Justice, AE, Chittoor, G, Gondalia, R, Phillip MeltonPhillip Melton, Lim, E, Grove, ML, Whitsel, EA, Liu, C-T, Cupples, LA, Fernandez-Rhodes, L, Guan, W, Bressler, J, Fornage, M, Boerwinkle, E, Li, Y, Demerath, E, Heard-Costa, N, Levy, D, Stewart, JD, Baccarelli, A, Hou, L, Conneely, K, Mori, MA, Beilin, LJ, Huang, R-C, Gordon-Larsen, P, Howard, AG, North, KE<p><strong>Aim:</strong> We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study.</p> <p><strong>Materials & methods:</strong> We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820).</p> <p><strong>Results & conclusion:</strong> We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near <i>TXNIP, ADCY7, SREBF1</i> and <i>RAP1GAP2</i> that had not previously been associated with obesity-related traits.</p>
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Publication title
EpigenomicsVolume
12Issue
17Pagination
1483-1499ISSN
1750-1911Department/School
Menzies Institute for Medical ResearchPublisher
Future Medicine Ltd.Place of publication
United KingdomRights statement
Copyright 2020 Future Medicine Ltd.Socio-economic Objectives
Public health (excl. specific population health) not elsewhere classifiedRepository Status
- Restricted
