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Mice that are congenic for the char2 locus are susceptible to malaria

journal contribution
posted on 2023-05-16, 20:26 authored by Burt, RA, Marshall, VM, Wagglen, J, Rodda, FR, Senyschen, D, Baldwin, TM, Buckingham, LA, Simon James FooteSimon James Foote
A major advance has been made towards the positional cloning of char2 (a quantitative trait locus encoding resistance to Plasmodium chabaudi malaria). Mice congenic for the locus have been used to fine map the gene and to prove that char2 plays a significant role in the outcome of malarial infection, independently of other resistance loci.

History

Publication title

Infection and Immunity

Volume

70

Issue

8

Pagination

4750-4753

ISSN

0019-9567

Department/School

Menzies Institute for Medical Research

Publisher

Amer Soc Microbiology

Place of publication

1752 N St Nw, Washington, USA, Dc, 20036-2904

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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    University Of Tasmania

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    In Copyright

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