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Mice that are congenic for the char2 locus are susceptible to malaria
journal contributionposted on 2023-05-16, 20:26 authored by Burt, RA, Marshall, VM, Wagglen, J, Rodda, FR, Senyschen, D, Baldwin, TM, Buckingham, LA, Simon James FooteSimon James Foote
A major advance has been made towards the positional cloning of char2 (a quantitative trait locus encoding resistance to Plasmodium chabaudi malaria). Mice congenic for the locus have been used to fine map the gene and to prove that char2 plays a significant role in the outcome of malarial infection, independently of other resistance loci.
Publication titleInfection and Immunity
Department/SchoolMenzies Institute for Medical Research
PublisherAmer Soc Microbiology
Place of publication1752 N St Nw, Washington, USA, Dc, 20036-2904