137743 - Micro RNA Expression after Ingestion of Fucoidan.pdf (411.13 kB)
Micro RNA expression after ingestion of fucoidan; a clinical study
journal contributionposted on 2023-05-20, 11:32 authored by Nuri GuvenNuri Guven, Spring, KJ, Sandra HolmesSandra Holmes, Kiran AhujaKiran Ahuja, Rajaraman Eri, Park, AY, Fitton, JH
Fucoidans are a class of fucose‐rich sulfated polysaccharides derived from brown macroalgae that exert a range of biological activities in vitro and in vivo. To generate an unbiased assessment of pathways and processes affected by fucoidan, a placebo‐controlled double‐blind pilot study was performed in healthy volunteers. Blood samples were taken immediately before and 24 h after ingestion of a single dose of 1 g of Undaria pinnatifida fucoidan (UPF) or placebo. Levels of isolated miRNAs were analyzed using Taqman Open Array Human MicroRNA panels. Out of 754 miRNAs screened, UPF affected a total of 53 miRNAs. Pathway analysis using the TALOS data analysis tool predicted 29 different pathways and processes that were largely grouped into cell surface receptor signaling, cancer‐related pathways, the majority of which were previously associated with fucoidans. However, this analysis also identified nine pathways and processes that have not been associated with fucoidans before. Overall, this study illustrates that even a single dose of fucoidans has the potential to affect the expression of genes related to fundamental cellular processes. Moreover, it confirms previous data that fucoidans influence immunity, cancer cells, inflammation, and neurological function.
Department of Industry, Innovation and Science
Marinova Pty Ltd
Publication titleMarine Drugs
Department/SchoolSchool of Pharmacy and Pharmacology
PublisherM D P I AG
Place of publicationSwitzerland
Rights statement© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).