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Midsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: A multicentre Australian cohort study

journal contribution
posted on 2023-05-19, 01:26 authored by Odenthal, C, Steve Simpson JRSteve Simpson JR, Oughton, J, Ingrid van der MeiIngrid van der Mei, Rose, S, Fripp, J, Lucas, R, Bruce TaylorBruce Taylor, Dear, K, Ponsonby, A-L, Coulthard, A
INTRODUCTION: Patients presenting with clinically isolated syndrome (CIS) may proceed to clinically definite multiple sclerosis (CDMS). Midsagittal corpus callosum area (CCA) is a surrogate marker for callosal atrophy, and can be obtained from a standard MRI study. This study explores the relationship between CCA measured at CIS presentation (baseline) and at 5 years post presentation, with conversion from CIS to CDMS. The association between CCA and markers of disability progression is explored.

METHODS: Corpus callosum area was measured on MRI scans at presentation and 5-year review following diagnosis of a first demyelinating event, or evidence of progressive MS, in 143 participants in the Ausimmune/AusLong Study. Relationships between CCA (at baseline and follow-up) and clinical outcomes were assessed.

RESULTS: Mean CCA at baseline study was 6.63 cm2 (SD 1.01). Patients who converted to MS by 5-year review (n = 100) had a significantly smaller mean CCA at follow-up (6.22 vs. 6.74, P = 0.007). Greater CCA reduction was associated with higher annualized relapse rate over follow-up.

CONCLUSION: Baseline CCA obtained from standard MRI protocols may be compared with subsequent MRI examinations as a surrogate for neurodegeneration and cerebral atrophy in patients with MS. This study demonstrates an association between CCA and disability in individuals presenting with CIS who convert to MS.

History

Publication title

Journal of Medical Imaging and Radiation Oncology

Volume

61

Issue

4

Pagination

453-460

ISSN

1754-9477

Department/School

Menzies Institute for Medical Research

Publisher

Wiley-Blackwell Publishing Asia

Place of publication

Australia

Rights statement

Copyright 2016 The Royal Australian and New Zealand College of Radiologists

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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