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Miniaturised electrically actuated high pressure injection valve for portable capillary liquid chromatography

journal contribution
posted on 2023-05-19, 14:32 authored by Li, Y, Pace, K, Nesterenko, PN, Brett PaullBrett Paull, Roger StanleyRoger Stanley, Miroslav MackaMiroslav Macka
A miniaturised high pressure 6-port injection valve has been designed and evaluated for its performance in order to facilitate the development of portable capillary high performance liquid chromatography (HPLC). The electrically actuated valve features a very small size (65 × 19 × 19 mm) and light weight (33 g), and therefore can be easily integrated in a miniaturised modular capillary LC system suited for portable field analysis. The internal volume of the injection valve was determined as 98 nL. The novel conical shape of the stator and rotor and the spring-loaded rotor performed well up to 32 MPa (4641 psi), the maximum operating pressure investigated. Suitability for application was demonstrated using a miniaturised capillary LC system applied to the chromatographic separation of a mixture of biogenic amines and common cations. The RSD (relative standard deviation) values of retention times and peak areas of 6 successive runs were 0.5–0.7% and 1.8–2.8% for the separation of biogenic amines, respectively, and 0.1–0.2% and 2.1–3.0% for the separation of cations, respectively. This performance was comparable with bench-top HPLC systems thus demonstrating the applicability of the valve for use in portable and miniaturised capillary HPLC systems.


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School of Natural Sciences


Elsevier Science Bv

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© 2017 Elsevier B.V.

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Expanding knowledge in the chemical sciences