posted on 2023-05-19, 01:39authored byStrakova, A, Ni Leathlobhair, M, Wang, G-D, Yin, T-T, Airikkala-Otter, I, Allen, JL, Allum, KM, Bansse-Issa, L, Bisson, JL, Castillo Domracheva, A, de Castro, KF, Corrigan, AM, Cran, HR, Crawford, JT, Cutter, SM, Delgadillo Keenan, L, Donelan, EM, Faramade, IA, Flores Reynoso, E, Fotopoulou, E, Fruean, SN, Gallardo-Arrieta, F, Glebova, O, Hafelin Manrique, RF, Henriques, JJGP, Ignatenko, N, Koenig, D, Lanza-Perea, M, Lobetti, R, Lopez Quintana, AM, Losfelt, T, Marino, G, Martincorena, I, Martinez Castaneda, S, Martinez-Lopez, MF, Meyer, M, Nakanwagi, B, De Nardi, AB, Neunzig, W, Nixon, SJ, Onsare, MM, Ortega-Pacheco, A, Peleteiro, MC, Ruth PyeRuth Pye, Reece, JF, Rojas Gutierrez, J, Sadia, H, Schmeling, SK, Shamanova, O, Ssuna, RK, Steenland-Smit, AE, Svitich, A, Thoya Ngoka, I, Vitalaru, BA, de Vos, AP, de Vos, JP, Walkinton, O, Wedge, DC, Wehrle-Martinez, AS, van der Wel, MG, Widdowson, SAE, Murchison, EP
Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.
History
Publication title
eLife
Volume
5
Article number
e14552
Number
e14552
Pagination
1-25
ISSN
2050-084X
Department/School
Menzies Institute for Medical Research
Publisher
eLife Sciences Publications Ltd.
Place of publication
United Kingdom
Rights statement
Copyright 2016 Strakova et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Repository Status
Open
Socio-economic Objectives
Expanding knowledge in the agricultural, food and veterinary sciences