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Mixed alkoxy/hydroxy 1,8-naphthalimides: expanded fluorescence colour palette and in vitro bioactivity
journal contribution
posted on 2023-05-20, 14:23 authored by Rudebeck, EE, Cox, RP, Bell, TDM, Acharya, R, Feng, Z, Nuri GuvenNuri Guven, Ashton, TD, Pfeffer, FMAn efficient and functional group tolerant route to access hydroxy 1,8-naphthalimides has been used to synthesise a range of monoand disubstituted hydroxy-1,8-naphthalimides with fluorescence emissions covering the visible spectrum. The dialkoxy substituted compounds prepared possess high quantum yields (up to 0.95) and long fluorescent lifetimes (up to 14 ns). The method has been used to generate scriptaid analogues that successfully inhibit HDAC6 in vitro with tubulin acetylation assays confirming that these compounds are more effective than tubastatin.
History
Publication title
Chemical CommunicationsVolume
56Issue
50Pagination
6866-6869ISSN
1359-7345Department/School
School of Pharmacy and PharmacologyPublisher
Royal Soc ChemistryPlace of publication
Thomas Graham House, Science Park, Milton Rd, Cambridge, England, Cambs, Cb4 0WfRights statement
© The Royal Society of Chemistry 2020Repository Status
- Restricted