University Of Tasmania

File(s) under permanent embargo

Multi-drug resistant Mycobacterium tuberculosis & oxidative stress complexity: Emerging need for novel drug delivery approaches

journal contribution
posted on 2023-05-21, 11:32 authored by Dua, K, Rapalli, VK, Shukla, SD, Singhvi, G, Madhur ShastriMadhur Shastri, Chellappan, DK, Satija, S, Mehta, M, Gulati, M, Pinto, TDJA, Gupta, G, Hansbro, PM
Tuberculosis (caused by Mycobacterium tuberculosis, Mtb) treatment involves multiple drug regimens for a prolonged period. However, the therapeutic benefit is often limited by poor patient compliance, subsequently leading to treatment failure and development of antibiotic resistance. Notably, oxidative stress is a crucial underlying factor that adversely influences the various treatment regimens in tuberculosis. Little information is available with advanced drug delivery systems that could be effectively utilized, in particular, for targeting the oxidative stress in tuberculosis. Thus, this presents an opportunity to review the utility of various available, controlled-release drug delivery systems (e.g., microspheres, liposomes, niosomes, solid lipid nanoparticles, dendrimers) that could be beneficial in tuberculosis treatments. This will help the biological and formulation scientists to pave a new path in formulating a treatment regimen for multi-drug resistant Mtb.


Publication title

Biomedicine and Pharmacotherapy








School of Pharmacy and Pharmacology


Editions Scientifiques Medicales Elsevier

Place of publication

23 Rue Linois, Paris, France, 75724

Rights statement

Copyright 2018 Elsevier Masson SAS.

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics