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Multidimensional capillary electrophoresis
journal contribution
posted on 2023-05-18, 16:07 authored by Grochocki, W, Markuszewski, MJ, Joselito QuirinoJoselito QuirinoMultidimensional separation where two or more orthogonal displacement mechanisms are combined is a promising approach to increase peak capacity in CE. The combinations allow dramatic improvement of analytical performance since the total peak capacity is given by a product of the peak capacities of all methods. The initial reports were concentrated on the construction of effective connections between capillaries for 2D analysis. Today, 2D and 3D CE systems are now able to separate real complex biological or environmental mixtures with good repeatability, improved resolution with minimal loss of sample. This review will present the developments in the field of multidimensional CE during the last 15 years. The endeavors in this specific field were on the development of interfaces, interface-free techniques including integrated separations, microdevices, and on-line sample concentration techniques to improve detection sensitivity.
History
Publication title
ElectrophoresisVolume
36Pagination
135-143ISSN
0173-0835Department/School
School of Natural SciencesPublisher
Wiley-V C H Verlag GmbhPlace of publication
Po Box 10 11 61, Weinheim, Germany, D-69451Rights statement
Copyright 2014 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimRepository Status
- Restricted