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Multiplexed dual second-dimension column comprehensive two-dimensional gas chromatography (GC x 2GC) using thermal modulation and contra-directional second-dimension columns
journal contributionposted on 2023-05-17, 20:50 authored by Savareear, B, Robert ShellieRobert Shellie
A multiplexed dual-secondary column comprehensive two-dimensional gas chromatography approach (GC × 2GC) designed for complex sample analysis is introduced. The approach splits the first-dimension column effluent into two second-dimension columns with different stationary phases, and recombines the two streams into one detector post-separation. The approach produces two single two-dimensional chromatograms for each injection. Careful manipulation of thermal modulator timing parameters combined with a novel contra-directional modulation regime facilitates this approach. A selection of 34 laboratory reference compounds containing n-alkanes, alcohols, aromatic hydrocarbons, ketones, esters and halogenated hydrocarbons were analysed to demonstrate the approach. The dual two-dimensional chromatogram from this single detector system provides complementary information due to the unique selectivity of the three separation columns. The results of this proof-of-principle investigation provide significant impetus for further development of GC × 2GC–MS methodology.
Publication titleAnalytica Chimica Acta
Department/SchoolSchool of Natural Sciences
Place of publicationNetherlands
Rights statementCopyright 2013 Elsevier B.V.